Abstract

It is yet unclear what kind of long-term effects such widespread brain damage would have. Apart from the etiology of subdural hematomas and coup injuries, which are characteristic of outer focal head trauma, widespread degeneration of cerebral white matter is linked to sagittal and lateral acceleration with centroaxial trauma. Diffuse axonal injury has a higher mortality rate than outer cerebral injury, with over 50% of sufferers passing away within two weeks. Methods: Between February 2022 to January 2023, at Department of Neurosurgery, Gandhi Medical College, Secunderabad, Hyderabad, Telangana, India, conducted a prospective cross-sectional research of 30 patients. Results: Pathognomonic lesions were found at autopsy in this investigation, even though CT brain scans were normal in most patients. Hypoxic changes including cellular swelling, Microhemorrages, white matter degeneration, and axonal swelling were observed on microscopic examination. The most frequent of these was hypoxic changes accompanied by cell enlargement. Conclusion: Our research shows that the results of a CT of the brain do not reliably predict how severe a patient's head injury would be. Studies performed after death have determined that hypoxia and free radicals were major contributors to death, specifically edema in the brain stem and corpus callosum. The researcher plans to tackle these issues in future studies by doing biochemical analytical studies and studies with larger samples.

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