Abstract

Sickle cell anaemia (SCA) is a genetic condition characterized by altered hemoglobin structure and function. This study aims to analyze various hematological parameters, emphasizing the haemoglobin to red cell count ratio, among patients with SCA in comparison to healthy controls. Methods: Hematological parameters including hemoglobin concentration, red cell count, and related ratios were measured for both SCA patients and healthy controls. Parameters were further analyzed based on gender and age demographics. Results: SCA patients consistently exhibited lower hemoglobin concentration and red cell counts compared to healthy controls. Despite the reduced counts, the hemoglobin to red cell count ratio remained comparable between the two groups. Gender-wise analysis revealed minimal variation in the Hb: RCC ratio. Age-wise breakdown showed a pronounced decline in hemoglobin levels for SCA patients across all age groups. Additionally, a slightly elevated Mean Corpuscular Hemoglobin (MCH) was observed in the SCA group, indicating higher hemoglobin content per red cell. Conclusions: The findings underline the adaptive erythrocytic alterations in SCA patients, which might be compensatory mechanisms to counterbalance the inherent reduced oxygen-carrying capacity. Understanding these alterations is crucial for developing targeted therapeutic strategies for SCA

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