Abstract

Dry eye syndrome is very common these days. Tear film properties are altered by systemic variables such as medicines and the environment, tear film is vital to maintaining a healthy ocular surface. In a psychiatric setting, anti-psychotic medications are routinely prescribed and often taken for the rest of a patient's life. Consequences are therefore frequently experienced. Materials and methods: This study was conducted at the Department of Ophthalmology, Narayana Medical College and Hospital, Nellore, Andhra Pradesh, India between August 2021 to January 2023. A cross-sectional observational study was conducted on 300 eyes of 150 chronic anti-psychotic patients. 90 men and 60 women comprised 150 patients. Schizophrenia was treated in 92 patients, delusional disorder in 30, psychoses in 15 and other diseases in 13. Results: Our research showed that 48 of 150 patients using these medications were affected by dry eye illness. It was found that patients who had been receiving treatment for longer than 8 years were more likely to develop dry eye disease. Patients on many medications, especially Chlorpromazine, then haloperidol, then risperidone, were found to be at a higher risk of developing dry eye. Conclusion: As a result, our research suggests that patients receiving long-term treatment with antipsychotics should have routine ocular follow-up visits for early diagnosis and treatment of dry eye

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