ISSN 0975-3583

Journal of Cardiovascular Disease Research

    Analyzing mean platelet volume and its relationship to the occurrence of acute ischemic stroke

    Dr. Vijaya Krishna Maanam, Dr. Prameela Rani Pamarthi
    JCDR. 2023: 63-73


    The purpose of the study was to investigate if there is a significant association with both MPV and ischemic stroke incidence, as well as if there is a significant association among stroke severity and mean platelet volume. The goal of this study is to determine if MPV is linked to the occurrence of ischemic stroke. The goal of this study is to determine if there is a statistically significant correlation between subtypes of stroke and MPV. The purpose of this study is to examine whether or not MPV is associated with the severity of ischemic stroke. Methods: From August 2021 to July 2022, at Department of General Medicine, Siddartha Medical College, Vijaywada, Andhra Pradesh, India, conducted a Case Control study. Fifty acute ischemic stroke patients who met the criteria presented within 48 hours of symptom onset. The Modified Rankin's scale assessed stroke severity. Automated analyzers measured mean platelet volume in EDTA and Citrate samples. MPV was assessed in 50 age- and gender-matched controls. Results: Acute ischemic stroke had higher mean platelet volume. With p = 0.005, mean platelet volume (MPV) is associated with ischemic stroke, with individuals experiencing 7.35+/-0.81 MPV and controls 6.94+/-0.59. MPV (EDTA) is 7.86+/-0.82 in cases and 7.58+/-0.70 in controls, but the variability is small (p value =0.074). Cases have a mean 2.56+/-0.58 (1.43-4.40) platelet count, while controls have 2.69+/-0.83 (1.60-5.40). This difference is not statistically significant (p value =0.380). Platelet mass, calculated from platelet count and MPV, is stable. Clinical stroke severity was not associated with MPV in this study (p value =0.281). Conclusion: This study found higher MPV in acute ischemic stroke. A rise in MPV independently predicts ischemic stroke after multivariate regression analysis. The findings suggest thrombopoiesis changes cause cerebral thrombosis with larger platelets. Platelet volume's role in stroke pathogenesis and outcome, especially in stroke-risk patients, needs further study.


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    Volume 14 Issue 2