Abstract

Melanoma is a highly aggressive cancer that exhibits metastasis to various critical organs. Unlike any other cancer cells, melanoma cells can synthesize melanin in large amounts, becoming heavily pigmented. Until now the role of melanin in melanoma, particularly the effect of melanin presence on the abilities of melanoma cells to spread and metastasize remains unknown. The employment of animal models to test therapeutic strategies against melanoma growth and metastatic spread is of key relevance for cancer biologists. The current research was focused to studythe anticancer effect on orange peel extract in melanoma tumour induced c57bl hybrid mice model. Significant reduction of tumour growth was found treated with Orange peel which was subcutaneously injected with B6F10 melanoma. Survival time was also increased in compare with control untreated tumour bearing mice. The orange peel hydromethanolic extract of (200mg/kg, 400mg/kg and 600mg/kg) drug dosing showed decrease in the micronucleus formation respectively.

Description