Abstract

Background & Methods: The aim of the study is to Antimicrobial efficacy of simarouba glauca leaf extract on dental plaque microorganisms. This research involved in-vitro studies to assess phytochemical constituents, antioxidant activity and antimicrobial efficacy of SG against dental plaque microorganisms and followed by formulation of mouthwash and in-vivo evaluation of antimicrobial efficacy by clinical assessment. Results: TPC of ESG and ASG was found to be 22.37±0.65 and 7.71±0.09mg/g GAE respectively and TFC were found to be 51.28±1.59 and 27.33±0.93 mg/g for ESG and ASG respectively. The results show that ESG contained phenol, flavonoid, nearly twice the concentration as that of the ASG. Analysis for TPC shows there is a significant difference between TPC with ESG and ASG (p= 0.031) and also there is a significant difference between TFC with ESG and ASG (p= 0.047). Values are expressed Mean ± SD for triplicates Conclusion: The increasing antibiotic resistance of many microorganisms has led to interest in finding of novel therapy for diseases of microbial origin. SG mouth wash is feasible to be used. It is effective against the most common oral microorganisms. Hence, this mouthwash might be well thought out as a simple and effective method for prevention and control of dental plaque and serve as an alternate to chlorhexidine.

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