Abstract

Urinary Tract Infections (UTIs) are among the most common bacterial infections worldwide. The rise in antimicrobial resistance poses a significant challenge in the management of UTIs. This study aims to assess the current antimicrobial susceptibility patterns in UTIs to guide effective treatment strategies. Methods: In this cross-sectional study, 200 patients diagnosed with UTIs at a tertiary care hospital were enrolled. Urine samples were cultured to isolate pathogens, which were then tested for antimicrobial susceptibility using standard disc diffusion methods. Demographic and clinical data were also collected. Results: The study predominantly included female patients aged 20-40 years. The most frequently isolated pathogens were Escherichia coli and Klebsiella pneumoniae. Antimicrobial susceptibility testing revealed varying levels of resistance, with E. coli showing a 25% resistance to Amoxicillin, 15% to Ciprofloxacin, and 5% to Nitrofurantoin, and K. pneumoniae exhibiting 17.5% resistance to Ceftriaxone and 10% to Meropenem. Notably, a significant proportion of Pseudomonas aeruginosa isolates displayed resistance to Piperacillin (20%) and Gentamicin (12.5%). These findings underscore the importance of tailored antimicrobial therapy based on local susceptibility patterns, especially in the context of emerging multidrug resistance. Conclusion: The study underscores the variable and evolving patterns of antimicrobial susceptibility in UTIs. These insights are critical for optimizing empirical treatment and combating antimicrobial resistance. Further research focusing on regional trends and resistance mechanisms is recommended to enhance UTI management strategies.

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