Abstract

Materials and methods: This randomised double blinded study included patients who underwent intraabdominal surgeries under general anaesthesia. Patients were divided into two groups,group A and B(22 patients in each group) receiving oral aprepitant(80mg) and single dose of intravenous ramosetron(0.3mg) respectively. Incidence and extent of nausea and vomiting, use of rescue antiemetics and number of post operative nausea and vomiting episodes in both the drug groups were assessed at 12,24 and 48 hours after the operation. Results: In patients receiving aprepitant(Group A) incidence and severity of post operative nausea and vomiting were found to be comparable to the same in the patients receiving ramosetron(Group B) in 12th,24th and 48th post operative hours. Conclusion: It was found that Aprepitant and Ramosetron had comparable efficacy in preventing PONV upto 48 hrs post operatively in patients having abdominal surgeries under general anaesthesia ,as well as in aspects of causing adverse effects. Number of patients who experienced nausea and vomiting postoperatively were less in the Group A population(Aprepitant group ) compared to the patients in Group B(Ramosetron group).

Description

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