Abstract

In subjects with type 2 diabetes mellitus, one of the most commonly seen disorders is dyslipidemia. The association of type 2 diabetes mellitus and dyslipidemia is established in the Caucasian subjects. However, the data establishing this link in the Indian subjects is scarce in the literature. Aim: The present study was conducted to assess the serum lipid profile parameters and their association with glucose intolerance status in prediabetics and type 3 diabetes mellitus subjects in Indian subjects. Methods: The present cross-sectional study included 1146 subjects from both genders. For all the subjects, demographics, fasting serum lipids including HDL-C (high-density lipoprotein cholesterol), LDL-C (low-density lipoprotein cholesterol), TG (triglycerides), and TC (total cholesterol), blood pressure, fasting glucose, and 2-hour OGTT (oral glucose tolerance test). Results: Odds ratio for 95% confidence interval for type 2 diabetics was 0.61 for LDL-C, 2.15 for HDL-C, 3.89 for triglycerides and 2.41 for total cholesterol. This was non-significant for LDL-C with p-value of 0.107. However, for HDL-C, triglycerides, and total cholesterol, these values were statistically significant with respective p-values of 0.04, <0.001, and <0.001. For prediabetics, odds ratio for LDL-C, HDL-C, triglycerides, and total cholesterol was 1.42, 2.95, 1.98, and 0.92 respectively. For LDL-C and total cholesterol, this was statistically non-significant with respective p-values of 0.733 and 0.194. However, for HDL-C and triglycerides, this difference was statistically significant with p-values of <0.001 and 0.01 respectively. For category 0, 1, 2, and 3 there were 6.02% (n=69), 1.04% (n=12), 63% (n=722), and 28.97% (n=332) cases. In diabetics, for category 0, 1, 2, and 3 there were 1.44% (n=1), 16.66% (n=2), 4.01% (n=29), and 16.86% (n=56) events. This was statistically significant for category 3 with p<0.001 and non-significant for category 1 and 2 with p-values of 0.007 and 0.08 respectively. Events for prediabetics were 2.89% (n=3), 8.33% (n=1), 8.03% (n=58), and 12.11% (n=39) respectively for category 0, 1, 2, and 3. This was statistically significant for category 2 and 3 with p-values of 0.03 and 0.002 respectively. Conclusion: The present study concludes that high levels of triglycerides and HDL-C parameter of dyslipidemia are seen in subjects with diabetes mellitus which increase proportionally with the increase in glucose intolerance. This points to regular lipid parameter monitoring in subjects with type 2 diabetes mellitus.

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