ISSN 0975-3583
 

Journal of Cardiovascular Disease Research



    ASSESSING THE SERUM LIPID PROFILE AND ITS ASSOCIATION WITH PREDIABETES AND DIABETES IN INDIAN SUBJECTS


    Dr. Prakash Khunte, Dr. B. Shobharani, Dr Sanjiv Kumar Singh, Dr. Vishal Agrawal
    JCDR. 2023: 319-325

    Abstract

    In subjects with type 2 diabetes mellitus, one of the most commonly seen disorders is dyslipidemia. The association of type 2 diabetes mellitus and dyslipidemia is established in the Caucasian subjects. However, the data establishing this link in the Indian subjects is scarce in the literature. Aim: The present study was conducted to assess the serum lipid profile parameters and their association with glucose intolerance status in prediabetics and type 3 diabetes mellitus subjects in Indian subjects. Methods: The present cross-sectional study included 1146 subjects from both genders. For all the subjects, demographics, fasting serum lipids including HDL-C (high-density lipoprotein cholesterol), LDL-C (low-density lipoprotein cholesterol), TG (triglycerides), and TC (total cholesterol), blood pressure, fasting glucose, and 2-hour OGTT (oral glucose tolerance test). Results: Odds ratio for 95% confidence interval for type 2 diabetics was 0.61 for LDL-C, 2.15 for HDL-C, 3.89 for triglycerides and 2.41 for total cholesterol. This was non-significant for LDL-C with p-value of 0.107. However, for HDL-C, triglycerides, and total cholesterol, these values were statistically significant with respective p-values of 0.04, <0.001, and <0.001. For prediabetics, odds ratio for LDL-C, HDL-C, triglycerides, and total cholesterol was 1.42, 2.95, 1.98, and 0.92 respectively. For LDL-C and total cholesterol, this was statistically non-significant with respective p-values of 0.733 and 0.194. However, for HDL-C and triglycerides, this difference was statistically significant with p-values of <0.001 and 0.01 respectively. For category 0, 1, 2, and 3 there were 6.02% (n=69), 1.04% (n=12), 63% (n=722), and 28.97% (n=332) cases. In diabetics, for category 0, 1, 2, and 3 there were 1.44% (n=1), 16.66% (n=2), 4.01% (n=29), and 16.86% (n=56) events. This was statistically significant for category 3 with p<0.001 and non-significant for category 1 and 2 with p-values of 0.007 and 0.08 respectively. Events for prediabetics were 2.89% (n=3), 8.33% (n=1), 8.03% (n=58), and 12.11% (n=39) respectively for category 0, 1, 2, and 3. This was statistically significant for category 2 and 3 with p-values of 0.03 and 0.002 respectively. Conclusion: The present study concludes that high levels of triglycerides and HDL-C parameter of dyslipidemia are seen in subjects with diabetes mellitus which increase proportionally with the increase in glucose intolerance. This points to regular lipid parameter monitoring in subjects with type 2 diabetes mellitus.

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    Volume 14 Issue 5

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