Abstract

Oxidative stress has been implicated in the pathogenesis of acute myocardial infarction. In recent years, cardiac troponin (cT) has revolutionized the diagnosis and management of acute myocardial infarction (AMI). But in India, most tertiary care hospitals are depending on creatinine kinase (CK), CK-MB, asparte transaminase (AST), and MDA for the diagnosis of AMI due to the unavailability of cT. Aim and objective: Assessment of Cardiac Enzyme Level and Lipid Peroxidation in Patients with Actute Myocardial Infarction at the Tertiary Care Teaching Hospital of Chhattisgarh. Material and method: The study was carried out in the Department of Cardiac and Biochemistry, SSIMS, Bhilai, C.G. patients, and 30- to 70-year-old age and sex-matched healthy controls. The patients who were recruited from the Critical Care Unit (SSIMS) were brought to the emergency room with a history of chest pain. Patients with chest pain were diagnosed to have AMI according to the clinical criteria: chest pain that lasted for more than 3 hours, ECG changes (ST elevation of 2mm or more in at least two leads), and elevation in total CK, CK-MB, and trop-I+ve. Result: We have found a significant increase in MDA, total CK, CK-MB, and AST (p< 0.001) and a significant decrease in total thiols (p< 0.001) in AMI patients as compared to healthy controls. Conclusion: Reactive oxygen species play a role in the pathogenesis of atherosclerosis, thus leading to acute coronary events.

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