Abstract

Hypertension is a significant risk factor for cardiovascular diseases, and oxidative stress has been implicated in its pathogenesis. This study aimed to investigate the levels of oxidative stress markers and their potential correlation with cardiovascular risk factors in hypertensive patients. Material and Methodology: A cross-sectional study was conducted on 200 participants, including 100 hypertensive patients and 100 normotensive individuals. The participants' blood pressure was measured, and various oxidative stress markers, including malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GPx), were measured in their blood samples. The association between oxidative stress markers and cardiovascular risk factors such as age, gender, smoking, body mass index (BMI), and lipid profile was analyzed using regression analysis. Results: Hypertensive patients had significantly higher levels of MDA and lower levels of SOD and GPx compared to normotensive individuals. Regression analysis showed a significant association between oxidative stress markers and cardiovascular risk factors such as age, gender, smoking, BMI, and lipid profile. Conclusion: This study suggests that oxidative stress may play a crucial role in the development of cardiovascular diseases in hypertensive patients. The association between oxidative stress markers and cardiovascular risk factors highlights the importance of early intervention to minimize associated risks. These findings have implications for the development of preventative strategies and personalized treatment plans for hypertensive patients.

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