Abstract

Biomarkers are a large range of quantitative and repeatable biological sign features. They are defined as "a trait that is objectively measured and analysed as a sign of normal biological mechanisms, pathogenic processes, or pharmacological reactions to a therapeutic strategy" in its broadest definition. Many novel biomarkers are still through early development, but it is still unclear how these indicators' roles and biochemistry connect to the likelihood of subsequent cardiac disease in people with and without coronary artery disease (CAD), as well as how useful they are clinical. Aims and Objective: The study aims to find the association of cardiac biomarkers with the occurrence of myocardial infarction (MI) and attempts to apply them in risk and prognostic determination. Methods: This is a prospective study that was conducted on 220 patients who visited our hospital in the outpatient department of cardiology or emergency department and were examined for biomarkers of MI along with their clinical features. The diagnosis of MI was made by applying criteria set by World Health Organization. The patients with diagnosed MI were considered in the MI group while those who did not have MI, were taken as control. The laboratory parameters were statistically analysed between the two groups to associate the risk of MI with each variable. Results: The study found that the cardiac biomarkers like hsCRP, CKMB, TnT, and MPO, were all significantly (p<0.05) more in the MI group as compared to the control group. It was shown that the biomarkers were significantly higher in the MI group than in the Control group (p<0.05). Conclusion: The study concluded that there is a high risk of having MI if these cardiac biomarkers come higher level and can be considered the risk and prognostic marker of MI.

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