Abstract

Depressed mood, loss of interest or pleasure, decreased energy, guilt or a sense of low self-worth, interrupted sleep or food, and trouble concentrating are all symptoms of depression, a common mental condition. Women are more likely than men to have it. Some indications and symptoms of depression include irritability, exhaustion, difficulty concentrating, difficulties making decisions and remembering things, and recurrent thoughts of death, dying, or suicide. There are many different factors that can contribute to depression, including heredity, chemical changes brought on by drug or alcohol abuse, family/marriage issues, medical conditions, natural disasters (fires, floods, storms), crime victims, financial difficulties, losses like the death of a loved one, and ageing. Material and Methods-This hospital-based case-control study comprised 50 diagnosed patients with depression under 18-65 age group who visited the psychiatric department as cases and 50 healthy individuals who were matched for age and gender and took part in the study as controls. After outlining the goals and specifics of the study, all participants in both groups provided written, fully informed consent. Serum TSH, T3, and T4 levels are calculated using ECi. Calcium, magnesium, and phosphorus are also determined using Vitros 4600. Results: Although T3 and T4 values were significantly lower (P=0.000 and P=0.004, respectively) and serum Ca levels were lower (P=0.000), TSH levels were significantly higher (P=0.076) in the depressed patients group. The levels of serum Po4 were considerably increased (P=0.004). The serum Mg levels were lower in the depression group (P=0.020). Conclusions: We conclude from the current study that the function of thyroid hormones (TSH, T3 and T4) and minerals (calcium, phosphorus, and magnesium) in depressed patients and compares their levels to those of healthy controls. As a result, depressed sufferers often have reduced thyroid hormone levels. Our observations of high serum Po4 levels and decreased Ca and Mg levels suggested that the thyroid gland was underactive. Numerous factors can cause the aforementioned minerals to fall out of equilibrium. More research should be done to determine how the aforementioned researched parameters affect the subject's mental behaviour.

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