Abstract

Purpose: We first sought to prospectively evaluate the relationship of PD to CVD and all-cause mortality using a national representative sample in the United States. Methods: A prospective study was carried out of 147 patients with a periodontal disease who referred for periodontal consultation.. The severity of PD was categorized as non-PD,modest and severe PD based on clinical attachment loss and pocket depth. Results: The levels of inflammation markers (high sensitivity C-reactive protein, white cell count and fibrinogen)were significantly higher in men with severe PD compared to men without PD (p < 0.05). The prospective associations were evaluated using multivariable Cox proportionalhazards models. After adjusting for age, gender, household income and traditional risk factors of CVD, severe PD was associated with an increase risk of CVD mortality and all-cause mortality in men aged 30–64 years (HR = 2.13 with 95% confidence interval of 1.37–3.31 for CVD mortality; HR = 1.64 with 95% confidence interval of 1.25–2.15 for all-cause mortality). In addition, significant linear trends were found in CVD and all-cause mortality across the severity of PD (p < 0.001). However, no significant associations were found in men aged ≥65 and in women. Conclusions: There appears to be prospective associations between PD and CVD and all-cause mortality in men aged 30–64 years. Inflammation may be one possible pathway to link PD with CVD.

Description

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