Abstract

Various diseases were suggested to be associated with the ABO blood group which is a crucial pathological process of primary knee arthritis. Recently, genome-wide studies revealed an association between the ABO gene and tumour necrosis factor α, as well as intercellular adhesion molecule 1 (ICAM-1), which are important pro-inflammatory cytokines and may have an impact on the systemic inflammatory response. Thus a disproportionate level of pro-inflammatory cytokines and inflammatory process play a vital role in the pathogenesis and progression of primary knee Osteoarthritis. This study aimed to determine whether ABO blood group may be associated with primary Osteoarthritis (OA). Materials and Methods This observational study is conducted in patients coming with known cases or newly diagnosed condition of primary osteoarthritis at the outpatient department in L. N. Medical College & Research Centre and associated J.K Hospital Bhopal (Madhya Pradesh). Results: Patients reported to the Department of medicine and orthopedics with the final diagnosis of primary knee osteoarthritis comprised of 450 patients with a prompt female predominance. The mean age of all the study participants observed from 67.4 ± 8.1 years (44 - 84 years). The control group consisted of 500 individuals with a slight female predominance and a observed mean age of 57.5 ± 10.42 years. These values showed that these parameters are statistically significant with the p – value of <0.001. Conclusion: To conclude, the results of this showed that a strong relationship was observed between blood group A and primary knee osteoarthritis. Likewise this study showed that weak relationship was seemed to be observed between AB blood group and knee osteoarthritis.

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