Abstract

Type 2 diabetes is the predominant form of diabetes worldwide, accounting for 90% of cases globally. Increased activity of hypothalmopituitary axis and elevated cortisol level may underlie metabolic syndrome and coronary artery disease in patients with Type 2DM. Aim and Objectives: To know association of serum cortisol level and prevalence of CAD among type 2 diabetes mellitus thus we have tried to find serum cortisol level and prevalence of CAD among type 2 diabetes patients in this study. Methods: This is a cross-sectional study conducted in, department of General Medicine, Guntur Medical College, Guntur, included 100 patients attending with type 2 diabetes mellitus, after following inclusion and exclusion criteria and approved by institutional ethical committee. Results: In our study total 120 patients were included after following inclusion and exclusion criterial, Out of patients was studied 44% were females and 56% were males. 50% was in the age group of 50- 60 years, 42% was in between 61-70% and only 8% patients contributes > 70 years. 54.17% was without coronary artery disease and 45.83% patients was associated with CAD. 24 showed elevated fasting cortisol level and rest were normal. Out of 120 patients studied, 55 had coronary artery disease. Among 24 patients with elevated cortisol, 19 were associated with coronary artery disease and association between serum cortisol level and coronary artery disease was statistically highly significant. Conclusion: There is an association of elevated cortisol and high prevalence of coronary artery disease in patients with type 2 DM. Also we have observed that, there was hyperactivity of hypothalamopituitary axis in type 2 DM patients.

Description