Abstract

Diabetes Mellitus is directly linked with the development of cardiovascular diseases, but there is very little documented information available regarding its association with C-reactive protein (CRP). Aim To analyze the association between CRP and cardiovascular diseases (CVD) in Type II Diabetes Mellitus patients. Material and Methods This was a case control observational study, carried out among 200 participant subjects (100 controls & 100 cases). Blood sample (5 ml) was collected from each subject and Serum was separated by centrifuging blood at 2000 rpm for 15 min, Estimation of CRP were done on semi-autoanalyzer (Robonikreadwell touch) in clinical biochemistry laboratory, lipid profile and other routine investigations by autoanalyser. All the statistical analysis was done by using the Windows based SPSS statistical package (Version 23.0) Student’s t-test and Pearson correlation analysis was applied and p-values <0.05 were taken as the significant. Results The mean value of CRP in the subjects with type II Diabetes Mellitus was 3.81 mg/L and in control was 2.20 mg/L (P<0.05). The weight and waist circumference, were also significantly different (P<0.05) between the study groups CRP had an insignificant correlation with the BMI (r= 0.15,p>0.05) as well as with waist circumference (r=0.18,p>0.05). Also significant correlation was found in between the HbA1c (%) & Blood glucose (F) (mg/dl). Conclusions The present study finding suggests that deranged blood sugar & HbA1c levels regulate the level of CRP that could lead to complication like CVD. Also, there is a strong degree of association between type II DM and CRP in the study.

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