Abstract

Diabetic patients have 2-4 folds higher Cardiovascular disease (CVD) risk when compared to non-diabetics. High HbA1c could be a sign of high triglycerides levels which may predict CVD risk factors in patients with type 2 Diabetes mellitus. Elevated TG: HDL-C ratio may be closely associated with poor glycemic control. The purpose of the study was to investigate the relationship between hemoglobin A1c and TG: HDL-C ratio in type 2 diabetic patients. The study included a total of 100 subjects in which 50 subjects with a history of T2DM for at least 5 years and 50 controls. Patients were assigned to two groups based on HbA1c, those with good glycemic control who had HbA1c ≤7.0 % and poor glycemic control who had HbA1c >7.0 %. For all subjects, HbA1c, FBS and lipid profile and TG/HDL-C ratios were assessed. Data analyzed using descriptive statistics and correlated by Pearson correlation coefficient. Results showed that higher Mean ±SD for lipid parameters, fasting blood sugar and HbA1c in T2DM cases than controls. There is highly significant correlation of TG: HDL-C ratio and HbA1C (r=0.347, p=0.0004) in subjects with poor glycemic control.HbA1c positively correlated with TC (r=0.0154, p=0.87), TG (r=0.295, p=0.002), whereas negatively correlated with HDL-C in subjects with poor glycemic control. These findings suggested that TG/HDL-C ratio should be focused in management of T2DM. A strong correlation between HbA1c and various lipid parameters especially TG/HDL-C ratio may suggest the importance of glycaemic control and dyslipidemia.

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