Abstract

Varicose veins are one of the most common long-term symptoms of vascular pathology and are related to various degrees of chronic venous insufficiency (CVI). Although it has been demonstrated that inflammation is induced in varicose veins, it is still unclear how inflammation contributes to vein wall remodelling. Objective: To evaluate the association of IL -18 (-607) C/A and (-137) G/C gene polymorphisms with primary varicose disease. Methods: In this study, a total of 73 patients and 73 healthy volunteers served as controls. All demographic and medical information was documented. Using PCR-RFLP, the gene polymorphisms IL -18 (607) C/A and IL -18 (137) G/C were found. Results: The proportion of age groups ≤20 years, 21-30 years, 31-40 years, 41-50 years, 51-60 years, and > 60 years was 4.11%, 24.66%, 28.77%, 17.81%, 16.44%, and 8.22%, respectively. The proportion of males and females was 79.45% and 19.18%, respectively. The genotypes of IL -18 (-607) C/A and IL -18 (-137) G/C were not significantly different in the case and control groups. Conclusion: The prevalence of primary varicose disease increases with age. The IL -18 (-607) C/A and (-137) G/C gene polymorphism was not associated with susceptibility to primary varicose disease and its clinicopathological development

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