Abstract

Asthma is characterized by continuous inflammation of the respiratory tract in children & adults. Twenty percent of all children suffer from asthma, making it a major global health issue. Recent studies have linked asthma to lipid metabolism. Poor lipid metabolism is connected to asthma. This study will contribute to our understanding of the role of Dyslipidemia in asthma & will help us to develop a more effective approach to treating the condition because similar studies on the association between lipid profile parameters & asthma are lacking from this state. Methods: The study was conducted on OPD & IPD patients >18 years old in the Department of Respiratory Medicine, TMMC&RC among 77 patients >18 years attending OPD & IPD & diagnosed as a case or a known case of asthma. The aim of the study was to analyse the association of lipid profile parameters with asthma severity. Results: Out of 77 subjects, 58.4% were males & 41.6% were females. Most of the age group of 18-30 years (40.26%) followed by 31-40 & 41-50 years. 21 out of total 77 patients had comorbidities (n=21,27.3%) out of which maximum patients had a history of tuberculosis (n=17,22.1%) followed by diabetes mellitus(n=1,1.3%) and only 1 patient had hypothyroidism (1.3%). Mean VLDL, TC (mg/dL), TG (mg/dL), HDL-C (mg/dL) & LDL-C (mg/dL) among the study subjects 26.44±11.69, 194.44±43.22, 121.11±76.68, 48.67±12.86 & 119.30±37.97 respectively. Mean FVC, FEV1 (Predicted), FEV1 (VOL), FEV1% & FEVI (% Predicted) among the study subjects was 3.24±0.67, 2.70±.62, 314.42±137.78, 22.82±11.73 & 56.62±20.65 respectively. VLDL, TC, HDL-C & LDL-C was found to be comparable w.r.t. asthma severity. TG was found maximum in subjects with severe asthma (151.12) followed by moderate (111.42) & mild asthma (109.65), though no significant difference was found. No significant association was found between BMI & asthma severity. HDL-C & LDL-C level were found to be comparable w.r.t. asthma severity overall. VLDL, TC, TG, HDL-C & LDL-C were found to be comparable w.r.t. asthma severity in subjects having BMI between >24.9. Conclusion: Many studies have associated oxidant-antioxidant imbalance resulting in dyslipidemia and associated asthma severity and many studies have observed no association between these two. TG was found maximum in subjects with severe asthma followed by moderate & mild asthma in subjects having BMI between 18.5-24.9 with statistically significant difference as p<0.05.

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