Abstract

Breast cancer is one of the most common cancers of all age group all over the world in the females. Role of lipid metabolism and obesity in different cancer development has been well studied but in this study we tried to find their association with breast cancer. Also we studied association of menopausal status with breast cancer. This study is to find any association of lipid profile, obesity and menopausal status in Breast cancer patients. Methods: A total of 70 histopathologically confirmed cases of breast cancer was included in this study and their lipid profile test was carried out using fully automated biochemistry analyser. Obesity was defined by body mass index (BMI) of 25 kg/m2 or greater as per the Asia-Pacific classification of BMI. Detailed clinical history along with menopausal status was taken and then all data was analysed using the Epi-info-7 software computer programme. Data was expressed as mean(x) and standard deviation (SD), using Mann-Whitney/Wilcoxon Two-Sample Test (Kruskal-Walli’s test for two groups) which was equivalent to Chi square. Results: Out of 70 cases, 56 (80%) cases had high BMI >25 (BMI (kg/m²) whereas 20% had normal BMI and it was significantly higher than control group. It has been found that Total cholesterol (TC), Low density lipoprotein (LDL), Very low density lipoprotein (VLDL) and Triglycerides (TGs) were raised in majority of breast cancer patients whereas High density lipoprotein (HDL) levels were low. Menopausal status was variable in both cases and control group. Conclusions: It was found that levels of plasma total cholesterol and TGs were specifically raised with high BMI among Breast cancer patients. HDL levels had inverse association with breast cancer. However no significant association was found with menopausal status of patients.

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