Journal of Cardiovascular Disease Research
Association of preoperative c-reactive protein (CRP), carcinoembryonic antigen (CEA), Glasgow prognostic score (GPS) and car (CRP/albumin ratio) with staging, recurrence and survival in colorectal carcinoma: A prospective observational study
Digvijoy Sharma, Nava Kishore K, Venu Madhav T, Surya Ramachandra Varma G, Jagan Mohan, Dr. N Bheerappa
JCDR. 2023: 636-653
Abstract
Colorectal carcinoma is the most common malignancy of the gastrointestinal tract. In India, colorectal cancer accounts for 7/1,00,000. Colorectal cancer only causes symptoms in 10% to 15% of patients early in the disease, and therefore screening is necessary for the early detection of colon cancer. Colonic cancers have a good prognosis provided they are detected early and treated aggressively. The search for better screening methods for cancers, including colorectal cancers, has led to tumor markers. An ideal tumor marker should be both specific and sensitive enough to detect small tumors for early diagnosis or during screening. This study was done to determine the significance and prognostic value of preoperative C-Reactive protein (CRP), Carcinoembryonic antigen (CEA) levels, GPS(Glasgow prognostic score) and CAR(CRP/Albumin ratio) in colorectal carcinomas (CRC). Correlation of CRP, CEA, CAR and GPS was done with staging and recurrence pattern of the disease
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