Abstract

Dyslipidemia and hypertension in diabetic patients increase the risk of microvascular as well as macrovascular complications. The risk is usually increased and even multiplied when both dyslipidemia and hypertension coexist. Aim of the study: This study aimed to evaluate the association of serum lipids with high blood pressure among diabetic patients. Methods: This prospective observational cohort study was conducted in National Center for Control of Rheumatic Fever & Heart Diseases, Dhaka, Bangladesh, from March 2021 to July 2022. Total 247 diabetic patients from different age groups of either gender were enrolled in this study. Patients taking lipid lowering agents were excluded. Demographic and clinical information as well as data regarding lipid profile and blood pressure of the participants was recorded. Results: Total cholesterol, triglycerides and LDL-C were significantly correlated with systolic as well as diastolic blood pressure and were raised among hypertensive patients as compared to non-hypertensive (P<0.001). The highest correlations were found between non-HDL-C with systolic and diastolic blood pressures (r=0.420 and r=0.421, respectively with p<0.001). However, HDL-C was inversely correlated with systolic and diastolic blood pressure and was raised among non-hypertensive patients. Regression models and mathematical linear equations were developed to estimate increasing blood pressure by given serum lipid levels. All regression models were significant (p<0.0001). Conclusion: High lipid levels contribute to development of increase systolic as well as diastolic blood pressures. Besides blood pressure checking, proper assessment of total-cholesterol, triglycerides and HDL-C, non-HDL-C levels should be considered as mandatory procedure in management of all diabetic patients.

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