Abstract

Background: The urinary N-acetyl-beta-Glucosaminidase can served as a early detectible marker for nephropathy in patients with type 2 diabetes mellitus. Materials and Methods: This cross-sectional study included total ninety (90) subjects, whereas sixty were type 2 diabetes mellitus cases and remaining thirty were healthy controls. For all the subjects biochemical, clinical and experimental parameters are studied. Results: The type 2 diabetes mellitus patients showed a significant increased levels of urinary N-acetyl-beta-Glucosaminidase when compared to healthy controls. Among, the cases the type 2 diabetes mellitus patients with microalbuminuria showed a significantly higher levels of urinary N-acetyl-beta-Glucosaminidase than the type diabetes mellitus with normoalbuminuria. The urinary N-acetyl-beta-Glucosaminidase levels are significant positive correlation with microalbumin and negative correlation with eGFR. Conclusion: The urinary N-acetyl-beta-Glucosaminidase determination might be used as early predictable marker for type 2 diabetic nephropathy.

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