Abstract

Background:To assess association of vitamin D and allergic disorders in children.Material and Methods:Eighty- four children with history of asthma and atopic dermatitis of either gender was selected. Patients were put in group I and healthy subjects (control) in group II. The severity of atopic dermatitis was evaluated using the Scoring Atopic Dermatitis Scale (SCORAD). Blood vitamin D level (ng/mL) was assessed using chemiluminescence phenomenon (CLIA).Results:Group I had 40 males and 44 females and group II had 42 males and 42 females. The mean vitamin D level in group I patients was 25.3 ng/ml and in group II was 33.8 ng/ml. A significant difference was observed in both groups (P< 0.05). Vitamin D level >20 ng/ml was seen in 26 subjects in group I and 54 in group II and vitamin D level <20 ng/ml in 58 in group I and 30 in group II. A significant difference was observed in both groups (P< 0.05). A non- significant difference was seen depicting non- association of concentration of total IgE antibodies, number of eosinophils and vitamin D (P> 0.05).Conclusion:There was higher concentration of total IgE antibodies and the number of eosinophils in patients with vitamin D deficiency

Description

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