Abstract

Aim: The present study is undertaken to study positivity of autologous serum skin test in patients suffering with chronic idiopathic urticaria Methodology: This is an experimental study. In the present study 100 clinically diagnosed cases of Chronic Idiopathic Urticaria attending the Department of Dermatology, Venereology & Leprosy at KIMS, Narketpally were taken. The study period was from 2019 December - 2020 August. Results: A total number of 100 cases of chronic idiopathic urticaria reporting to the Dermatology Venereology Leprology department, Osmania General Hospital were studied. 46 of them were females and 54 were males. Maximum cases were in the age group of 21-30 years (33%), followed by age group 31- 40 years (26%). The age of the youngest patient was 14 years and that of the oldest was 65 years. Autoantibodies, detected by ASST, were seen in the sera of 43% patients with CIU, comparable to available reports in literature. Presence of autoantibodies was unrelated to gender and the mean age of onset of the disease was earlier in ASST positive patients. Presence of these autoantibodies was significantly associated with more duration of disease, more duration of wheal, frequent attacks of disease and UAS > 5. Angioedema and Abnormal Thyroid profile were significant in ASST positive patients. There was difference in presentation of clinical symptoms between ASST positive and negative patients but these were not statistically significant. There was difference in CBP, AEC, ESR, RBS Sr IgE Levels and ANA between positive and negative ASST patients, but these results were statistically insignificant.

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