Abstract

Aged Garlic Extract Protects Liver and Kidney Cells from Damage Caused by Streptozocin-Nicotinamide in Rats. Streptozocin-nicotinamide (STZ-NA) is a chemical compound that is used to induce diabetes in rats. It works by damaging the beta cells in the pancreas, which are responsible for producing insulin. Insulin is a hormone that helps the body to use glucose for energy. Aged garlic extract (AGE) is a dietary supplement made from garlic that has been fermented for several weeks or months. It is a rich source of antioxidants, which can help protect cells from damage caused by free radicals. Free radicals are unstable molecules that can react with other molecules in the body, causing damage that can lead to chronic diseases such as cancer, heart disease, and stroke. In this study, rats that were given AGE after being treated with STZ-NA had significantly lower levels of oxidative stress and inflammation in their livers and kidneys than rats that were not given AGE. AGE also helped to improve the function of the beta cells in the pancreas, which led to lower blood sugar levels. These findings suggest that AGE may be a potential treatment for diabetic complications by protecting cells from damage caused by oxidative stress. However, more research is needed to confirm these findings and to determine the optimal dose and duration of AGE treatment.

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