Abstract

Platelets play vital roles in repair of the minute vascular damages in day to day life, wound repair, the innate immune response and metastatic tumour cell biology. AIMS AND OBJECTIVES: The aim of our study was to examine bone marrow aspiration smears for changes in megakaryocytes in patients with thrombocytopenia. MATERIALS AND METHODS: It was a prospective study carried out from June 2022 to June 2023. A series of 53 bone marrow aspirates were examined in patients with thrombocytopenia to look for changes in megakaryocytes. RESULTS: Out of the 53 cases megakaryocytes were suppressed in 20 cases (37%), inadequate in 9 cases (17%), hypoactive in 11 cases (21%), absent in 6 cases (11.5%) and adequate in 7cases (13.5%) of thrombocytopenia. In our study nutritional deficiency was the most common cause of thrombocytopenia. CONCLUSION: Peripheral blood and bone marrow examination is crucial for patients with thrombocytopenia. Understanding the morphological changes of megakaryocytes in bone marrow aspirates can improve the diagnostic accuracy.

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