Abstract

To evaluate and compare lipoprotein A and uric ucid in patients of psoriasis and its correlation with severity of the disease and associated cardiovascular disease risk. Methods: Present study conducted in the dept. of biochemistry M.Y.H. Our study included 80 subjects which were divided into two groups, group A comprising 40 apparently healthy controls and group B comprising 40 patients of psoriasis, which is again divided into subgroups, group C comprising of 25 mild cases of psoriasis and group D comprising of 15 moderate/ severe cases of psoriasis. Subjects were enrolled in the study as per the inclusion criteria. Severity of the disease was assessed by PASI(Psoriasis Area and Severity Index) score. Fasting blood samples were collected and evaluated for Lipid profile, lipoprotein ‘a’ and uric acid , risk ratio was calculated. Results: Mean level of Lp(a) was higher in cases as compared to control but the difference was not significant statistically. Difference between control and moderate/severe psoriasis were highly significant .Differences between mild and moderate/severe psoriasis patients were significant. Difference in serum uric acid between all the groups except between control and mild cases of psoriasis were highly significant statistically. Difference in risk ratios between group A and group B were significant and difference in risk ratios between group A and group D and in between group C and D were highly significant statistically.Conclusion: Patients of psoriasis must be considered as a group at high risk for cardiovascular diseases. Lipid derangements correlate with the severity of disease and also act as a good prognostic sign. We conclude that psoriatic patients should be evaluated and followed up for the risk of dyslipidemia and cardiovascular morbidity

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