Journal of Cardiovascular Disease Research
Case study of Methotrexate induced oral ulcers
Dr. Amit Dubey Dr. Ankur Singh Baghel Dr. Ashish Sharma Dr. Rahul Bharaskar
JCDR. 2023: 1712-1717
Abstract
Methotrexate is well established drug in the treatment of various neoplastic diseases. More recently it has become use full as once-weekly, low-dose treatment of disorders such as psoriasis and rheumatoid arthritis. Clinical trials have shown its effectiveness in these conditions and it is likely that dentists will encounter patients taking this drug in general dental practice. Oral ulceration can occur as a side effect of methotrexate therapy. This may be due to lack of folic acid supplementation or overdosage due to confusion regarding its once-weekly regime
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