Journal of Cardiovascular Disease Research
CEFTRIAXONE BLOCKS THE POLYMERIZATION OF Α‑SYNUCLEIN AND EXERTS NEUROPROTECTIVE EFFECTS IN VITRO
ANCHURI NAGARAJU
JCDR. 2020: 57-67
Abstract
The β-lactam antibiotic ceftriaxone was suggested as a therapeutic agent in several neurodegenerative disorders, either for its ability to counteract glutamate-mediated toxicity, as in cerebral ischemia, or for its ability to enhance the degradation of misfolded proteins, as in Alexander’s disease.
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