Abstract

To assess the various drug reaction cutaneous pattern types. to research the prevalence and distribution of drug eruptions in relation to sex, age, administration method, associated infections, and other diseases. Methods: This is a retrospective study. The 50 patients were selected for this study at Department of D.V.L, Orthopaedics, Dental Surgery, MGM Hospital, Warangal from October 2020 to and March 2022. Results: The most common cutaneous adverse drug reaction seen in our patients were maculopapular rashes found to be the commonest with 18 patients (comprising 36% of the total), followed by fixed drug eruption in 13 patients (26%), urticaria in 6 patients (12%), Stevens Johnson syndrome in 4 patients (8%), erythema multiforme in 4 patients (8%) and others (including Toxic epidermal necrolysis, erythromelalgia, glossitis, lichenoid drug reaction and Dapsone syndrome) 5 (10%). The most frequent cause of CADRs in both adults and children is the use of antibiotics, with NSAID-acting medications coming in close second. The most frequent trigger for FDE is NSAIDs, specifically paracetamol. Generalized rashes were found to be more prevalent than localized rashes (52% vs. 48%) in terms of pattern of distribution. The mean period of onset for the various drug eruption were almost similar with other studies. It was 14 days for maculopapular reactions and Stevens Johnson syndrome. 13 days for toxic epidermal necrolysis, 23 days for drug hypersensitivity syndrome, 3 days for urticaria and 1 day for fixed drug eruption. Conclusion: Cutaneous adverse cutaneous drug reactions occur most commonly in the 21-30 years age group with mean age of 26 years. CADRs were found to be more common in the females than in males

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