Abstract

Pseudoexfoliation glaucoma (PXG) is more aggressive than Primary open angle glaucoma; Intraocular pressure (IOP) is higher, IOP fluctuations are excessive, and there is substantial damage to the optic nerve and visual field. Resistance to medical management, aggressive nature, and increased intraoperative complications of PXG make it distinct entity from primary open angle glaucoma. So, this study was conducted to analyze the prevalence of glaucoma in Pseudoexfoliation syndrome (PXS) and its clinical spectrum. Methodology: This was a hospital based, descriptive study done between February 2021 to August 2022, where patients satisfying the inclusion criteria were recruited for the study. Detailed history was taken. Visual acuity, anterior segment examination, IOP, gonioscopy, fundus examination visual field analysis, contrast sensitivity were evaluated. PXG was diagnosed based on pseudoexfoliative material on slit lamp examination, IOP>21 mm Hg, glaucomatous cupping, pigmentation of trabecular meshwork and visual field defects. Results: Prevalence of glaucoma in patients with PXS was 35.2%. Prevalence and laterality of PXS increases with increase in age and more common in males. Iris and lens were the most common sites for Pseudoexfoliation (PXF) material. Nuclear cataract was predominant in PXS. Central corneal thickness (CCT) in patients with PXG was found to be thinner that patients with PXS. Mean IOP in PXG was higher than in PXS. High-pressure glaucoma, Open angle glaucoma and unilateral glaucoma was most common type of glaucoma in PXG, which showed increased severity of optic disc damage and advanced field defects. Interpretation & conclusion: Thus, in view of high prevalence of glaucoma and aggressive nature of glaucoma in PXS leading to blindness, all elderly patients should be screened for PXS and patients with PXS should undergo complete glaucoma evaluation and follow up and treatment to prevent blindness

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