Abstract

The majority of perimenopausal women's health issues are related to abnormal uterine bleeding. AUB is defined as uterine corpus bleeding that is abnormal in regularity, volume, frequency, or duration and takes place when there is no pregnancy. Perimenopause occurs 2-8 years before menopause and 1 year after the last period. Study the range of histopathological findings in endometrial samples with a clinical history of abnormal uterine bleeding in the 40-51 age group. To assess the endometrium's hormone receptor markers, ER, PR, and HER-2/neu. Methods: A prospective study was conducted over a period of 24 months on 200 patients aged between 40-51 years with AUB excluding adenomyosis and leiomyoma patients. Of these, 74 cases which included all the cases of benign endometrial hyperplasia (36), endometrial intraepithelial neoplasia (29) and endometrial carcinoma (09) were evaluated for ER, PR and HER-2/NEU expression. Results: The most common histopathological pattern was benign endometrial hyperplasia (18%). Expression of PR receptors was high in glands and stroma compared to ER in benign hyperplasia, EIN and endometrial carcinoma. Expression of ER and PR receptors was high in glands compared to stroma. A significant difference was noted in ER and PR expression in stroma between EIN and Endometrial carcinoma cases. Her2-neu was positive only in one case of endometrial carcinoma. Conclusion: In order to identify patients with elevated levels of ER and PR receptors who might benefit from medications that target these receptors and potentially stop the progression of hyperplasia to EIN, invasive surgical procedures are avoided by using immunohistochemical estimation of estrogen and progesterone receptors in endometrial aspirate samples

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