Abstract

Hemodynamic stress response due to laryngoscopy and tracheal intubation may produce adverse effects like tachycardia, hypertension which can lead to intraoperative myocardial ischemia and intracerebral haemorrhage.Our aim was to compare the potency of oral clonidine and oral pregabalin in attenuating the stress response due to laryngoscopy and tracheal intubation in posterior fossa surgery. 60 patients of ASA ( I/II), posted for posterior fossa surgeries under general anaesthesia were included in the study. All the patients were devided into two groups. Group A received oral clonidine 0.3mg and group B received oral pregabalin 150mg, 90 minutes before surgery with a sip of water.Standard anaesthesia was administered. Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), mean arterial pressure (MAP) and heart rate were recorded preoperatively, after premedication, immediately after intubation, then at 1 min, 3 min, 5 min, 10 min and 15 min after intubation. Level of sedation, postoperative pain scores and any adverse effects were also noted and compared.Both drugs were effective in attenuating haemodynamic stress response due to laryngoscopy and tracheal intubation. Post-operative analgesia was better in pregabalin group and clonidine group produced lesser sedation.Both the drugs can be used to attenuate the hemodynamic stress response to laryngoscopy and endo tracheal intubation without any adverse effects.Pregabalin produced better analgesia and clonidine produced lesser sedation.

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