Abstract

BACKGROUND This study was conducted to determine as to whether the co-induction strategy influences the overall amount of propofol required for induction, perhaps mitigating the related detrimental effects on haemodynamics. METHODS This hospital-based study was conducted from August 2009 to July 2011 at the Department of Anaesthesiology, Regional Institute of Medical Sciences, Imphal, Manipur, among 120 ASA I and II patients, aged 18 to 60, undergoing elective general and gynaecological surgeries under general anaesthesia. The study was approved by the institutional ethics committee, and the participants provided written informed consent. RESULTS According to the results of the paired "t" test conducted within the groups to measure heart rate at the two distinct intervals, group I and group 11 had significantly higher heart rates at the conclusion of the induction period. When the heart rates of the groups were compared before and after induction, it was seen that there were substantial differences between groups 1 and 11, I vs. III, I vs. IV, II vs. III, and II vs. IV. At the conclusion of induction, it was discovered that all groups I, II, III, and IV had significant reductions in systolic blood pressure from baseline levels. When the SBP (Systolic Blood Pressure) changes between the groups were compared before and after the induction, it was seen that there were significant differences between groups I and II, I and III, I and IV, II and III, II and IV, and III and IV. It was discovered that there was a substantial difference in the mean diastolic blood pressure distribution among the four groups both prior to and following induction. The diastolic blood pressure results at different time intervals for each group are shown in the paired "t" test results, which show that group I vs. II, I vs. III, I vs. IV, II vs. III, II vs. IV, and III vs. IV were significant. The MAP (Mean Arterial Pressure) comparison between the study groups reveals that all four groups' "p" values were deemed significant. The study determined that there was a significant difference in MAP between groups I vs. II, I vs. III, I vs. IV, II vs. III, II vs. IV, and III vs. IV prior to and after induction. The "f" test ANOVA result showed a statistically significant difference between the groups for the total dose of propofol. With a 'p' value of less than 0.05, groups II, III, and IV use less propofol than group I.

Description