Abstract

The aim of the present study was to compare anti-hemorrhagic effect of uterotonics and Tranexamic acid (TXA) for postpartum hemorrhage. Methods: The prospective observational study was conducted in the department of gynecology. 200 pregnant women who were booked in this hospital and delivered vaginally and clinically diagnosed with postpartum hemorrhage were taken for the study. 100 patients received standard protocol with placebo and 100 received standard protocol with Tranexamic acid 1 gm IV. Results: Majority of the patients belonged to age group 19-24 years 60% in group A and 56% in group B respectively followed by 26-30 years, i.e., 25% in group A and 24% in group B. According to parity, 60% belonged to multipara in group A and 65% in group B. 91% and 90% patients delivered full term normal delivery in group A and group B respectively. Two groups are comparable with respect to delivery. P value is significant (p< 0.0001). There was significant difference in FTND and VBAC. Mean blood loss in the control group was 750 ml +/- 100ml while that in study group was 650ml +/- 100ml. the difference between the two groups was significantly high and hence it was statistically significant (p< 0.0001). Conclusion: Tranexamic acid significantly reduces bleeding in post-partum haemorrhage. TXA is not a new drug and is generally well tolerated without any thrombogenic side effects. This data strongly supports the need for double blind study to investigate the potential effects of Tranexamic acid to reduce incidence of PPH and related maternal morbidity and mortality

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