Abstract

Microneedling followed by methotrexate 1% gel versus microneedling followed by tacrolimus solution (0.1%) in localised stable vitiligo Materials & Methods: 50 patients with localized stable vitiligo were enrolled after meeting the inclusion and exclusion criteria. They were randomly divided into 2 groups of 25 patients each. In Group A Methotrexate 1% gel was applied and in Group B Tacrolimus ointment (0.1%) was applied and dressing was done and changed after 24 hours. Then the patients were advised to apply the agent twice daily. This procedure was repeated at 3 weekly intervals till 24 weeks. In Group A and Group B microneedling with methotrexate gel and tacrolimus solution respectively was done with subsequent dressings. The procedure was repeated every three weeks for maximum 6 months. Vitiligo Area Severity Index (VASI) was used for evaluation of results. Analysis of results was done by using SPSS software. Results: While analysing the outcome statistically, it was seen that at 12 weeks and 36 weeks follow-up, significantly better outcome was observed among subjects of group A in comparison to subjects of group B. However; while comparing the incidence of complications in between the two study groups, non-significant results were obtained. Conclusion: Microneedling followed by methotrexate 1% gel in comparison to microneedling followed by tacrolimus solution (0.1%) in localised stable vitiligo showed significantly better improvement.

Description