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Journal of Cardiovascular Disease Research

2021, Vol: 8, Issue: 8
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    Comparative Study Between Natural And Synthetic Polymers On Drug Release Of Sustain Release Matrix Tablets Of Nevirapine


    Sk. Irfan Khan, Sk. Waseem Uddin, Velisetty Alekya, Anurag Rai, J. Satya Sri, Shaik Shabbeer, K. N. V. Rao
    JCDR. 2023: 1972-1981

    Abstract

    The aim of present investigation was to develop sustain release matrix tablets for sustain release drug delivery of nevirapine. The medication used for the treatment of HIV infected patients. The drug delivery system was designed to deliver the drug for such a time when it could be needed for patient conditions. The sustain release matrix tablets containing nevirapine in the inner core were formulated by direct compression method with an outer coating of different concentration of natural and synthetic polymers (HPMC, MCC, PECTIN). The release profile of sustain release matrix tablets exhibited a lag time. The optimized batch F5 gave good disintegration & dissolution of percentage drug release of tablet. So, on this basis we have concluded that the F5 formulation containing the pectin 50mg which is going to be selected as best formulation

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    Volume 14 Issue 7

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