Abstract

This was a randomized, double-blinded study conducted on 140 patients in the age group of 18-60 years, belonging to ASA I and II undergoing elective short gynecological procedures of duration less than 30 minutes at Kurnool Medical College.The study population was divided into two groups with patients of Group A receiving ketamine-propofol in the ratio 1:4 and Group B receiving ketamine-propofol in the ratio 1:2. All patients were induced with the study drug at a dose of 0.1ml/kg. The maintenance of anesthesia was with an infusion at 0.3ml/kg/hr for both groups. A bolus of 2ml of the study drug was given when an adequate depth of sedation was not maintained due to surgical stimulus.The study aimed to compare and evaluate the effectiveness of the two drug regimens of ketamine-propofol combination(1:4 and 1:2) with respect to quality of sedation and analgesia in the intra-operative period. The secondary objectives were to compare the change in hemodynamic variables, the need for airway interventions, the time for awakening after the procedure, incidence of post operative nausea and vomiting, incidence of recovery agitation and recall of intraoperative events

Description