Abstract

This study was done to compare the efficacy of bolus injection of Dexmedetomidine and Labetalol in attenuating the sympathoadrenal response accompanying laryngoscopy and endotracheal intubation in 60 patients divided into 2 groups.Group D - Dexmedetomidine 1µ/Kg Group L - Labetalol 0.5mg/Kg.60 patients of ASA I and II aged 18– 60 years undergoing neurosurgery under general anesthesia were chosen for the study. After obtaining ethical committee approval, the study population was chosen.Informed written consent obtained from the patient. Heart rate, systolic and diastolic blood pressure and oxygen saturation were recorded as base line value.All patients were monitored with ECG, pulse oximetry continuously and NIBP at 5 min intervals. Patients received study drug 5 min prior to induction according to the group. SBP, DBP, MAP, HR and SpO2 were monitored 1 minute after infusion of study drug, 1 minute after induction and 1,3,5,10 and 15 minutes after intubation.Results were tabulated and analysed. There was a reduction in the heart rate and mean arterial pressure response to intubation in both Dexmedetomidine and Labetalol groups , but when both the groups were compared there was statistically significant reduction of heart rate and arterial pressure response to intubation in Dexmedetomidine group. (P < 0.05).

Description