Abstract

Background: The most common consequence of all cardiac disorders, heart failure is a clinical condition that is the predominant factor in morbidity, death, and hospitalization in this patient population. Present study was aimed to compare neutrophil-to-lymphocyte ratio (NLR) to N-terminal pro-b-type natriuretic peptide (NTproBNP) in predicting severity of heart failure in patients with acute decompensated heart failure. Material and Methods: Present study was single-center, prospective, observational study, conducted in patients of age > 18 years, either gender, admitted with symptoms and signs of acute decompensated heart failure. The NLR was computed as the ratio of neutrophil to lymphocyte percentage. In addition, samples for NT-pro BNP were collected at the time of admission from research participants. Results: During the course of treatment, 12 patients (15 %) expired in the hospital. Total of 12 patients were died during the course of treatment. Among that 8 patients had an admission NLR of more than 7.75. Only 4 patients with NLR less than 7.75 were died in the hospital. NLR > 7.75 was significantly associated with mortality. Among 12 patients who died, 10 patients had an admission NT-PRO-BNP of more than 5635. NT-PRO-BNP > 5635 was significantly associated with mortality (p<0.001). In present study, higher levels of NLR, NT-PRO-BNP were significantly associated with ICU admission & prolonged hospital stay. In present study, higher levels of NLR, NT-PRO-BNP were significantly associated with reduced EF thus severity of heart failure. Conclusion: In patients with acute decompensated HF, NLR is a clinically useful, cost-effective value that forecasts in-hospital mortality, length of hospital stay & severity of heart failure.

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