Abstract

Cervical ripening or cervical softening is a process that is necessary for both spontaneous labor and labor induction. Prior to initiating induction, cervical ripening should be considered if bishop score of cervix is 6 or less than 6. Varying drugs and dosage are used for the same. Aim: The role of mifepristone for cervical ripening prior to labor induction and oral misoprostol solution (fixed dose) for labour induction are two such regimen studied and analysed in our study. Methods: A cross- sectional comparative study involving 100 patients (50 mifepristone, 50 misoprostol group) was done at a tertiary care hospital over a period of one year. Two groups were made- Group 1 patients were subjected to tab mifepristone 200 mg orally stat followed by another dose of 200mg after 24 hours. Group 2 were given oral misoprostol solution (fixed dose) for 24 hours. Bishop score on admission and after 12 hour and after 24 hour is calculated and compared in both groups. Results: The data analyzed as per protocol analysis, increase in bishop score was seen in both groups after 12 and 24 hours, but in group 1 patients only 50% patients developed cervical ripening in 1st 12 hour whereas in group2, 84% patients had ripened cervix within first 12 hours of study. At the end 66% patients in group 1 and 72% patients in group 2 delivered vaginally. Uterine hyperstimulation and meconium passage and aspiration are the seen more with group2 patients. No major side effects were observed in both groups. 4 patients were lost to follow up in mifepristone group.

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