ISSN 0975-3583

Journal of Cardiovascular Disease Research

    Comparative study of regimen mifepristone and misoprostol with misoprostol alone at first trimester termination of pregnancy

    Chinthareddy Varalakshmi, Dr. Tadepalli Harika, Dr. D Hymavathi
    JCDR. 2023: 773-779


    A broad array of drugs have been studied for first trimester medical abortion. Studies evaluating different regimens show varying results related to safety, efficacy and other outcomes. Thus, the objectives of this study was to (1) compare the success rates of abortion at First Trimester of Pregnancy, (2) study the side effects of the drugs, and (3) To study the acceptability in the both groups of abortion < 84 days of gestation. Methods: This study was conducted on medical abortion with the given regimen of Mifepristone 200 mg orally and Misoprostol 800 mcg vaginally/orally/sublingually and is compared with only Misoprostol 800 mcg. This study was conducted in the Department of Obstetrics and Gynecology, Katuri Medical College and hospital during the course of years between 2020 November to –2022 October. In total 300 cases were taken for the study and divided into two groups. Results: The combined regimen of Mifepristone and Misoprostol (group A) shown very much efficient as compared with only Misoprostol (group B) with low incidence of side effects (10.32%) and high success rate (97.34%) and acceptability (97.34%) and achieved abortion with in < 4hr induction - abortion (83.34%). The combined regimen comparatively showed least failure rate (2.66%) than group B (33.34%). Conclusion: As per present study that medical methods of abortion are effective, safe and reliable for termination of pregnancy of ≤84 days of gestation. The combined regimen of mifepristone and misoprostol was more effective than the sole administration of Misoprostol and proved its reliability for termination of pregnancy <84 days of gestation. More robust studies evaluating both the different combination and misoprostol alone regimens are needed to strengthen existing evidence as well as assess patient perspectives towards a particular regimen.


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