Abstract

The objective of this study was to compare the efficacy and success rates of two different techniques, chemical cauterization and fat plug myringoplasty, for the closure of tympanic membrane perforation in a cohort of 100 patients. Methods: A prospective study was conducted on 100 patients who presented with tympanic membrane perforation. The patients were randomly divided into two groups: Group A (n=50) underwent chemical cauterization, while Group B (n=50) underwent fat plug myringoplasty. The size and location of the perforations were documented for each patient. The success of the procedure was evaluated at regular intervals over a period of 12 months. Data were analyzed using appropriate statistical tests, and p-values were calculated to determine the significance of the results. Results: In Group A, the closure rate of tympanic membrane perforation after chemical cauterization was 76%. The average time for complete closure was 3.2 months (±0.8 months). In Group B, the closure rate after fat plug myringoplasty was 92%, which was significantly higher than Group A (p<0.05). The average time for complete closure was 2.1 months (±0.6 months). Furthermore, in Group B, the size of the perforation was found to be inversely correlated with the success rate of closure (p<0.01). Conclusion: Fat plug myringoplasty demonstrated a higher success rate and shorter time to complete closure compared to chemical cauterization for the closure of tympanic membrane perforation. The results indicate that fat plug myringoplasty is a more effective technique for the management of tympanic membrane perforation, especially for larger perforations. Further studies with larger sample sizes are warranted to validate these findings and provide more comprehensive evidence.

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