Abstract

Aims and objectives: This prospective, interventional, randomized and comparative study would be conducted to compare dexmedetomidine and clonidine for the attenuation of the sympathoadrenal response to laryngoscopy and endotracheal intubation. Material and methods: The study would be conducted in total of 150 patients aged 18 – 60 years of either sex. The patients would be randomly assigned to either of the three groups, each having 50 patients, using block randomization. Then either of three pretreatment medications would be given as per group: GROUP 1 (Isotonic saline, IS): 20ml of isotonic saline infused over 10 mins. GROUP 2 (Dexmedetomidine, D): Dexmedetomidine 100mcg dissolved in 20 ml of isotonic saline, infused @1mcg/kg body weight over 10 mins. GROUP 3 (Clonidine group): Clonidine 100mcg dissolved in 20 ml of isotonic saline, infused @1mcg/kg body weight over 10 mins. Results: The difference in SBP, DBP, MAP and HR between the groups was statistically not significant at 5 mins after drug infusion and highly significant at 10 mins after drug infusion, after induction with propofol, before intubation, and at 1, 3, 5 minutes after intubation and significant at 7 minutes after intubation. Conclusion: We observed that dexmedetomidine was far superior to clonidine in the attenuation of the pressor response and furthermore, dexmedetomidine was also helpful in providing conscious sedation without any respiratory depression with very few side effects.

Description

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