Abstract

Materials and Methods: This prospective study was conducted on 120 parturients undergoing cesarean section under spinal anesthesia.They were divided into three groups of 40 each. Group C received 0.9% normal saline(10ml),Group B received 8 mg ondansetron in normal saline (10ml).Group A received 4 mg ondansetron in normal saline (10ml).All the three drugs were administered 5 min before spinal anesthesia. Incidence of hypotension, vasopressor requirement, and side effects were evaluated. Results: Incidence of intraoperative hypotension was significantly high in group C(67.5%) as compared to group A(45%) and group B(20%). Significant difference in incidence of hypotension was also found between A and B groups. Total requirement of ephedrine was significantly higher in group C (5.68 ± 4.62mg) as compared to group A (3.14 ± 4.85mg) and B (1.65 ± 3.94mg). This was significantly higher in group A when compared with group B..Fall in mean HR, SBP, DBP, MAP was more in group C at different time intervals compared to other two groups. Conclusions: Ondansetron before spinal anesthesia reduced the incidence of hypotension and requirement of vasopressors in parturients undergoing cesarean section under spinal anesthesia.

Description

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