Abstract

:Laparoscopic surgeries, despite being minimally invasive, is not popular as a day care surgery because of the post operative pain and requirement of intravenous analgesic drugs. The aim of this study is to compare the efficacy of intraperitoneal instillation of levobupivacaine alone versus levobupivacaine with different doses of dexmedetomidine for post operative analgesia in patients undergoing laparoscopic cholecystectomy. Materials and Methods: Prospective observational study. In the study, 100 patients, scheduled for elective laparoscopic cholecystectomy after getting informed and written consent were taken up and were randomised into 4 groups to receive either 50 ml of 0.25% levobupivacaine + 5ml normal saline [GROUP A], 50ml of 0.25% levobupivacaine + dexmedetomidine 0.5mcg/kg diluted in 5ml normal saline [GROUP B], 50ml of 0.25% levobupivacaine + dexmedetomidine 1mcg/kg diluted in 5ml normal saline [GROUP C], 50ml of 0.25% levobupivacaine + dexmedetomidine 1.5mcg/kg diluted in 5ml normal saline [GROUP D]. Study drug was instilled before the removal of the trocar at the end of the surgery. All the patients also received infiltration of 0.25% bupivacaine at the port sites. Post operative pain using NRS, time to first rescue analgesia and total analgesic requirement of the patients amongst all the four groups was observed and compared. RESULTS: The mean NRS was found to be significantly lesser in Groups C & D as compared to Groups A & B. Inj. Fentanyl [1-2mcg/kg] was used as rescue analgesia for patients with NRS>4. Patients belonging to Group A received rescue analgesia earlier and higher as compared with Group B. Patients belonging to Group C & D did not require any rescue analgesia.

Description

.