Abstract

Laryngoscopy, tracheal intubation and subsequent extubation are often associated with an increase in sympathetic response which causes an increase in arterial blood pressure, heart rate, arrhythmias and raised Intracranial Pressure & Intraocular Pressure. Many pharmacological agents have been identified to attenuate the hemodynamic responses associated with intubation and extubation. Methods: An institutional-based 2-year comparative study between magnesium sulphate and lignocaine hydrochloride on 60 adult patients aged between 18-65 years divided into two groups of 30 each. The hemodynamic parameters like heart rate, systolic, diastolic and mean arterial blood pressure at was compared between the two groups. Results: Raise in HR, SBP, DBP and MAP at 0 minutes post-intubation (immediately after intubation) were significant in both the groups. The attenuation of the increase in HR and SBP was significantly better with magnesium sulphate compared to lignocaine from 0 minutes post-intubation. At 5 minutes post-intubation SBP and MAP were decreased significantly in the Magnesium Sulphate group, but in Lignocaine group vitals did not decrease significantly though they had taken a decreasing trend. At 10 minutes post-intubation only SBP and MAP were decreased significantly from baseline in Lignocaine group, but in Magnesium sulphate group all the vitals remained decreased. Conclusion: Our study concludes that Magnesium Sulphate is more effective than Lignocaine Hydrochloride in attenuating cardiovascular response to laryngoscopy and tracheal intubation.

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